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How Do Opioids Like Hydrocodone and Codeine Affect the Liver?
Opioids such as hydrocodone and codeine are widely prescribed for pain management, but their impact on the liver is an important health consideration. These medications are primarily metabolized by the liver’s cytochrome P450 enzyme system, particularly CYP2D6 and CYP3A4. During this process, the liver converts the drugs into their active or inactive metabolites. While occasional, …